Zynga carries out planned games shutdown, including “Petville”






SAN FRANCISCO (Reuters) – Social games publisher Zynga Inc confirmed on Monday that it has carried out 11 of the planned shutdowns of 13 game titles, with “Petville” being the latest game on which it pulled the plug.


Zynga in October said it would shut down 13 underperforming titles after warning that its revenues were slowing as gamers fled from its once-popular titles published on the Facebook platform in large numbers and sharply revised its full-year outlook.






The San Francisco-based company announced the “Petville” shutdown two weeks ago on its Facebook page. All the 11 shutdowns occurred in December.


The 11 titles shut down or closed to new players include role-playing game “Mafia Wars 2,” “Vampire Wars,” “ForestVille” and “FishVille.”


“In place of ‘PetVille,’ we encourage you to play other Zynga games like ‘Castleville,’ ‘Chefville,’ ‘Farmville 2,’ ‘Mafia Wars’ and ‘Yoville,’” the company told players on its ‘PetVille’ Facebook page. “PetVille” players were offered a one-time, complimentary bonus package for virtual goods in those games.


“Petville,” which lets users adopt virtual pets, has 7.5 million likes on Facebook but only 60,000 daily active users, according to AppData. About 1,260 users commented on the game’s Facebook page, some lamenting the game’s shutdown.


Zynga has said it is shifting focus to capture growth in mobile games. It also applied this month for a preliminary application to run real-money gambling games in Nevada.


Zynga is hoping that a lucrative real-money market could make up for declining revenue from games like “FarmVille” and other fading titles that still generate the bulk of its sales.


Zynga shares were up 1 percent at $ 2.36 in afternoon trade on Monday on the Nasdaq.


(Reporting By Malathi Nayak; Editing by Leslie Adler)


Gaming News Headlines – Yahoo! News





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Redskins win NFC East, Broncos get top seed in AFC


RG3 and the Washington Redskins are heading to the playoffs as NFC East champions.


By winning their seventh straight game, the Redskins rolled to their first division title in 13 years with a 28-18 victory over the Dallas Cowboys on Sunday night. Next up for Robert Griffin III & Co.: a home playoff matchup next Sunday with the Seahawks — the third straight postseason game for Washington against Seattle.


"It's just a mindset change," the rookie quarterback said. "When you have all these guys coming to work every day, putting it on the line, we knew we couldn't afford to lose one game, we made sure we didn't"


Thanks to Houston's late-season slump, Denver and New England will have byes when the AFC playoffs begin next week.


The Texans fell from first to third in the conference Sunday when they lost 28-16 at Indianapolis, which welcomed back coach Chuck Pagano after nearly three months of treatments for leukemia.


AFC West champion Denver won its 11th straight game, 38-3 over Kansas City to secure the top seed. New England blanked Miami 28-0 for the second spot.


Minnesota edged Green Bay 37-34 to grab the final NFC wild card, sinking the Packers to the third seed. Those teams will meet again next Saturday night at Lambeau Field.


The other NFC matchup will have Seattle (11-5), which beat St. Louis 20-13, at Washington on Sunday at 4:30 p.m. ET.


Cincinnati (10-6) will be at Houston on Saturday at 4:30 p.m. ET, and Indianapolis (11-5) goes to at Baltimore (10-6) on Sunday at 1 p.m. in the AFC wild-card rounds.


The divisional round games will be hosted by Denver on Saturday, Jan. 12, followed by San Francisco (11-4-1) at night. On Sunday, Jan. 13, Atlanta (13-3) will host the early game, followed by New England (12-4).


Peyton Manning threw for three touchdowns as Denver (13-3) routed the Chiefs. New England got the second seed despite having the same record as Houston because it beat the Texans, who lost three of their final four games.


Adrian Peterson had 199 yards against the Packers, finishing with 2,097 — Dickerson's single-season rushing mark in 2,105. But it was rookie kicker Blair Walsh who won it with a 29-yard field goal as time expired.


"Ultimately we got the 'W,'" Peterson said. "I told myself to come into this game focused on one thing, and that's winning."


Green Bay would have been seeded second in the NFC by beating Minnesota.


"The road got a little tougher having to play on opening weekend, but we've got a home game and that's why you win the division," Aaron Rodgers said. "We get to go back home, and the game will be different. They won't have home-crowd advantage, and hopefully that will make a difference."


Baltimore Pro Bowl safety Ed Reed is looking forward to a reunion with Pagano. He wishes it would come a little later in the postseason.


"Chuck's like a dad to me," Reed said "He means a lot to me. I would have much rather seen them in the AFC championship game than the first game."


But Reed will see him next week at Baltimore.


The Ravens had a chance to move up to the AFC's third seed with a win and a New England loss. But Baltimore lost at Cincinnati as both teams played backups for much of the game.


Pagano coached the Ravens' secondary for three seasons and was promoted to coordinator last year. Players and coaches in Baltimore have kept in touch, offering encouragement as he fought through the cancer treatments.


"Going back to Baltimore, obviously there's some familiarity there," Pagano said. "We had four great years there as a family. It's a top-notch organization, you know, really good football club. It's a great challenge and they have a great team and they have great players all over the place."


The Colts were 2-14 last season and chose quarterback Andrew Luck with the top selection in the draft. Luck and offensive coordinator Bruce Arians, who stepped in as interim coach with Pagano sidelined, led the turnaround.


Next week, Pagano goes up against former boss John Harbaugh.


"I love his family, and he's one of my closest personal friends in coaching," Harbaugh said. "What he's been through is phenomenal, but we're all competitors so that gets set aside."


Houston beat Cincinnati in the opening round of last year's playoffs.


"I think it will be good," said Bengals QB Andy Dalton, who grew up in suburban Houston. "We played there last year and know the atmosphere and what it's going to be like. The experience last year will definitely help us."


The defending Super Bowl champion Giants are out of contention. When Chicago beat Detroit 26-24, the Giants (9-7) were eliminated, even though they routed Philadelphia 42-7.


"It hurts," said Eli Manning. "Each year you want to make the playoffs to give yourself an opportunity to win a championship; 9-7 last year was good enough. It wasn't good enough this year and we knew it wouldn't be."


Minnesota's win eliminated Chicago.


___


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F.D.A. Approves Sirturo, a New Tuberculosis Drug





The Food and Drug Administration announced on Monday that it had approved a new treatment for multidrug-resistant tuberculosis that can be used as an alternative when other drugs fail.




The drug, to be called Sirturo, was discovered by scientists at Janssen, the pharmaceuticals unit of Johnson & Johnson, and is the first in a new class of drugs that aims to treat the drug-resistant strain of the disease.


Tuberculosis is a highly infectious disease that is transmitted through the air and usually affects the lungs but can also affect other parts of the body, including the brain and kidneys. It is considered one of the world’s most serious public health threats. Although rare in the United States, multidrug-resistant tuberculosis is a growing problem elsewhere in the world, especially in poorer countries. About 12 million people worldwide had tuberculosis in 2011, according to Johnson & Johnson, and about 630,000 had multidrug-resistant TB.


A study in September in The Lancet found that almost 44 percent of patients with tuberculosis in countries like Russia, Peru and Thailand showed resistance to at least one second-line drug, or a medicine used after another drug had already failed.


Treating drug-resistant tuberculosis can take years and can cost 200 times as much as treating the ordinary form of the disease


“This is quite a milestone in the story of therapy for TB,” Dr. Paul Stoffels, the chief scientific officer at Johnson & Johnson, said in an interview. He said the approval was the first time in 40 years that the agency had approved a drug that attacked tuberculosis in a different way from the current treatments on the market. Sirturo works by inhibiting an enzyme needed by the tuberculosis bacteria to replicate and spread throughout the body.


Sirturo, also known as bedaquiline, would be used on top of the standard treatment, which is a combination of several drugs. Patients with drug-resistant tuberculosis often must be treated for 18 to 24 months.


Even as it announced the approval, however, the F.D.A. also issued some words of caution.


“Multidrug-resistant tuberculosis poses a serious health threat throughout the world, and Sirturo provides much-needed treatment for patients who have don’t have other therapeutic options available,” Edward Cox, director of the office of antimicrobial products in the F.D.A.’s center for drug evaluation and research, said in a statement. “However, because the drug also carries some significant risks, doctors should make sure they use it appropriately and only in patients who don’t have other treatment options.”


The consumer advocacy group Public Citizen opposed approval in a letter to the F.D.A. in mid-December, saying that the results of a limited clinical trial showed that patients using bedaquiline were five times as likely to die than those on the standard drug regimen to treat the disease.


“Given that bedaquiline belongs to an entirely new class of drugs, it is entirely feasible that death in some cases was due to some unmeasured toxicity of the drug,” the letter said.


Sirturo carries a so-called black box warning for patients and health care professionals that the drug can affect the heart’s electrical activity, which could lead to an abnormal and potentially fatal heart rhythm. The warning also notes deaths in patients treated with Sirturo. Nine patients who received Sirturo died compared with two patients who received a placebo. Five of the deaths in the Sirturo group and all of the deaths in the placebo arm seemed to be related to tuberculosis, but no consistent reason for the deaths in the remaining Sirturo-treated patients could be identified.


Doctors Without Borders and the Bill and Melinda Gates Foundation, both active in the fight against tuberculosis and other global diseases, applauded the F.D.A.’s decision.


Jan Gheuens, interim director of the TB Program for the Gates Foundation, called it a “long-awaited event” and said the fight against TB had not benefited from new drugs in the way H.I.V. had. Beyond the benefits of the drug itself, he said the quick approval process could be a model for other drugs sorely needed in the developing world.


He also suggested, however, that more trials should be conducted to get a better understanding of the side effects that led to the black box warning.


The F.D.A. approved bedaquiline under an accelerated program that allows the agency to conditionally approve drugs that are viewed as filling unmet medical needs with less than the usual evidence that they work. The drug’s approval was based on studies that showed it killed bacteria more quickly than a control group taking the standard regimen, but it did not measure whether in the end patients actually fared better on bedaquiline. Johnson & Johnson will conduct larger clinical trials to investigate whether the drug performs as predicted.


In a statement responding to Public Citizen’s letter, a spokeswoman for Johnson & Johnson said the company was committed to supporting appropriate use of Sirturo and would “work to ensure Sirturo is used only where treatment alternatives are not available.”


Dr. Stoffels said the hope was that other new tuberculosis drugs would also be approved that, when used in combination with bedaquiline, could shorten and simplify the current standard of treatment. “That is still a long time away,” he acknowledged, but “this is a first step in a new regimen for TB.”


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Times Reporter in China Is Forced to Leave Over Visa Issue





BEIJING — A correspondent for The New York Times was forced to leave mainland China on Monday after the authorities declined to issue him a visa for 2013 by year’s end.




Chris Buckley, a 45-year-old Australian who has worked as a correspondent in China since 2000, rejoined The Times in September after working for Reuters. The Times applied for Mr. Buckley to be accredited to replace a correspondent who was reassigned, but the authorities did not act before Dec. 31, despite numerous requests. That forced Mr. Buckley, his partner and their daughter to fly to Hong Kong on Monday.


Normally, requests to transfer visas are processed in a matter of weeks or a couple of months.


The Times is also waiting for its new Beijing bureau chief, Philip P. Pan, to be accredited. Mr. Pan applied in March, but his visa has not been processed.


The visa troubles come amid government pressure on the foreign news media over investigations into the finances of senior Chinese leaders, a delicate subject. Corruption is widely reported in China, but top leaders are considered off limits.


On the day that The Times published a long investigation into the riches of the family of Prime Minister Wen Jiabao, both its English-language Web site and its new Chinese-language site were blocked within China, and they remain so.


In June, the authorities blocked the English-language site of Bloomberg News after it published a detailed investigation into the family riches of China’s new top leader, Xi Jinping. Chinese financial institutions say they have been instructed by officials not to buy Bloomberg’s computer terminals, a lucrative source of income for the company.


The Ministry of Foreign Affairs declined to comment on Mr. Buckley’s forced departure. Ministry officials have not said if they are linking Mr. Buckley’s visa renewal or Mr. Pan’s press accreditation to the newspaper’s coverage of China. In a statement, The Times urged the authorities to process Mr. Buckley’s visa as quickly as possible so that he and his family could return to Beijing.


“I hope the Chinese authorities will issue him a new visa as soon as possible and allow Chris and his family to return to Beijing,” Jill Abramson, the executive editor of The Times, said in the statement. “I also hope that Phil Pan, whose application for journalist credentials has been pending for months, will also be issued a visa to serve as our bureau chief in Beijing.”


The Times has six other accredited correspondents in China, and their visas were renewed for 2013 in a timely manner. David Barboza, the Shanghai bureau chief, who wrote the articles about Mr. Wen’s family, was among those whose visas were renewed.


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Mexico City Journal: Mobile Factory With Hope for a Better Life – Mexico City Journal





MEXICO CITY — The sound of a surprising opportunity rose above the tumult of traffic. “Factory for electronic textiles offering work,” came the message, shouted from a megaphone that sat in the basket of a white bicycle pedaled by Amor Muñoz, an artist in a black jumpsuit. “One hundred pesos an hour!”




Even on the streets of this busy capital, where sales pitches flow from speakers attached to anything with wheels, the offer stood out. Work? For about $7.50 an hour, a little above the American minimum wage?


The rush was on. By the time Ms. Muñoz parked in her usual spot outside a hospital in one of Mexico City’s peripheral neighborhoods, a line had already formed. Women of all ages squeezed together — one held a baby, another was nearly too old to walk — as Ms. Muñoz opened up a white wooden box revealing thread, needles, cloth, timecards and employment contracts. The work involved creating interactive art pieces that combine the old craft of sewing with 20th-century electronics and 21st-century tags allowing smartphone users to look up who worked on a given piece.


“It’s about community,” Ms. Muñoz said. “I’m interested in sharing the experience of art.”


If that were her only interest, it would be enough to make alpha geeks swoon; a local glossy magazine and the technology Web site Ars Technica recently honored Ms. Muñoz with their annual awards. But behind her vintage glasses and dimpled smile, Ms. Muñoz has a sharper message.


Her maquiladora, or factory, she said, is a “fantasy” meant to condemn the harsh reality of a global economy that uses and discards poor workers, especially women, to keep prices low.


In Mexico these days the project amounts to artistic subversion. At a time when the country’s new president, Enrique Peña Nieto, is trying to recast Mexico as an economic marvel, with growth rates surpassing Brazil, Ms. Muñoz’s factory is a countervailing force — a mobile reality check highlighting Mexico’s darker economic truths.


Take wages. The minimum wage in Mexico is about 60 cents an hour, and while the average pay in manufacturing has grown over the past decade, it is still only about $3.50 an hour, according to government statistics. Even according to higher estimates by the Bureau of Labor Statistics in Washington, Mexico’s hourly compensation costs are still only two-thirds of those found in Brazil, where the benefits of economic growth have helped a larger share of workers rise from poverty.


Economists recognize the problem. “We need to increase wages to become a true modern country,” said Luis de la Calle, a former Mexican government official who helped negotiate the North American Free Trade Agreement. But as Mexico tries to improve its image and gloss over its violent drug war, government officials have mostly described Mexico’s low wages in positive terms, as a way to compete with China. The market, it is generally assumed, will eventually drive up wages.


Ms. Muñoz is unwilling to wait. She described Mexican wages as an insult to human dignity, and every time her mobile factory appears, the power of work for reasonable pay goes on display. The crowds that gather are typically large. Sometimes people push and shove for two hours of work and $15, though once the day’s employees are selected (first come first hired), a calm tends to follow.


Earlier this month, the team included nearly a dozen women and one young man, all that Ms. Muñoz could afford. Many, like Sara Peregrino, 50, were homemakers with sewing experience. Others, like David Quiróz, 18, a taxi dispatcher, struggled to thread a needle without drawing blood.


Nearly everyone said the money they earned would go to one of two things — food or Christmas presents. “For women, it’s very hard to find a good job,” said Patricia Zamora, 33, a mother of two who arrived with Ms. Peregrino, one of her neighbors. “There is a lot of work for not much pay.”


Many of the women seemed to appreciate a chance to be involved in an art project. María González, 75, smiled widely when handed a needle and adjusted her purple scarf, excited to be creating something rather than worrying about her husband in the hospital. “This,” she said, sewing without looking down, “is a wonderful distraction.”


Ms. Muñoz seemed to agree. She stood nearby, waiting for her favorite time of day — when she paid the workers and took their photographs, which she would post online, linked to the artwork. It is an effort to make the workers more visible, she said, but also hints at her working-class past.


She grew up playing among the hammers and nails of the hardware store her parents owned in a marginal neighborhood like the one with her factory. She said she always appreciated manual labor and never felt comfortable in an office, even after receiving a law degree.


Textiles had once been a hobby — she used to collect huipiles, the traditional woven tunics of Mexico and Central America — but when she decided to become an artist in 2006, she returned to cloth and sewing. Her work now involves a mixture of textiles and technology. Many of her pieces involve sewn images with circuits that let users push buttons for sounds or displays of light.


Completed works from the mobile maquiladora project, for example, will create the whine of an ambulance siren.


Like many other young artists in the capital, she is trying to push Mexico forward by combining older traditions with the interactivity of social media and open-source software development. She dreams of finding financing for more mobile factories, and her lack of faith in government and industry is matched only by the optimism she expresses when discussing the power of networked youth.


“With technology, everything can be democratized,” she said. “It’s fabulous.”


Still, the human interactions are what she values most, so when Ms. Peregrino suddenly appeared and presented her with a pink plastic bag after being paid, Ms. Muñoz was visibly touched. The two women hugged as Ms. Muñoz put the gift in into the bicycle basket with the megaphone. Only later did she look inside, finding a hand-sewn purple scarf that must have taken days to complete.


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Kobe Bryant Finally Joins Twitter — Kind Of






Long among the sports world’s biggest Twitter holdouts, Kobe Bryant has finally joined the social network. But he hasn’t opened an account, and won’t be around for long.


Social savvy fans are being blessed with his presence thanks to Nike Basketball, which has turned over its account to Bryant since Tuesday.






[More from Mashable: Avery Johnson’s Teenage Son Unloads on Twitter After NBA Firing]


Nike Basketball, which sponsors Bryant and produces his official sneaker, announced the Kobe takeover in a Christmas Day tweet. The account’s name is now “Kobe Bryant” although its handle remains @nikebasketball. Kobe has spent the past few days tweeting about a variety of subjects using a series of hashtags that play off the theme #counton-fill-in-the-blank.


He’s tweeted about the Lakers progress as a team:


[More from Mashable: FanDuel Is Fantasy Sports With a Twist]


He’s tweeted behind-the-scenes snippets of training and treatment:


And he’s tweeted a totally normal, typical, everyday holiday family portrait:


Bryant actually joined Twitter for realsies back in 2011, but then deleted the account after racking up more than 35,000 followers in a just a few hours. He’s one of the NBA’s few stars without a Twitter presence. Nearly 90% of the league’s players are on the social network, according to Twitter.


But Bryant did become much more active on Facebook this summer, especially while traveling with the United States’ Olympic basketball team. He has nearly 15 million fans there, and reportedly writes his status updates and messages himself, with editing and actual posting done by support staff. In November he asked Facebook fans whether to join Instagram or Twitter next, and on Monday hinted in a status update that he may soon open an Instagram account.


What athletes would you most like to see get more active on social media? Let us know in the comments.


BONUS: 30 Must-Follow Twitter Accounts This NBA SEASON


1. @NBA


The NBA is arguably the world’s most engaging sports league on social media. Follow its official Twitter account for news, highlights and promotions.


Click here to view this gallery.


Thumbnail image courtesy Flickr, Keith Allison


This story originally published on Mashable here.


Social Media News Headlines – Yahoo! News





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Peterson, Vikings top Pack 37-34 to make playoffs


MINNEAPOLIS (AP) — Adrian Peterson picked up the Minnesota Vikings and gave them a ride to the playoffs, where the first stop on this improbable journey is, yes, Green Bay.


Peterson came up 9 yards shy of breaking Eric Dickerson's single-season record, but he still powered the Vikings past the Packers 37-34 Sunday with 199 yards to set up a rematch next weekend in a first-round playoff game.


Peterson sliced through the line for a 27-yard gain in the closing seconds, his career-high 34th carry. That set up Blair Walsh's 29-yard field goal as time expired and put the Vikings (10-6) in the postseason after consecutive last-place finishes.


The division champion Packers (11-5) dropped to the NFC's No. 3 seed.


Aaron Rodgers completed 28 of 40 passes for 365 yards and four touchdowns and no turnovers, connecting with Jordy Nelson from 2 yards to tie the game with 2:54 remaining. But Christian Ponder threw for three scores, including one to Peterson, providing the necessary balance.


Ponder didn't turn over the ball, either, and went 16 for 28 for 234 yards, including a 65-yard zinger in stride to Jarius Wright midway through the fourth quarter that set up Ponder's third touchdown toss.


Peterson finished with 2,097 yards, becoming the seventh player in NFL history to reach the 2,000 mark. He had to work for it, pulling out all the cutbacks, stutter-steps and spins he could find in his exceptional skill set. His longest run was only 28 yards against a defense geared to slow him down, and the first contact often came at, near or behind the line of scrimmage.


The Packers cut the lead to 27-24 late in the third quarter on a touchdown reception by James Jones. The on-field ruling was a fumble at the goal line, triggering an automatic review. Because the Packers threw the challenge flag after the replay process began, however, they were only penalized for unsportsmanlike conduct, not prevented from benefiting from the overturned call.


That's what happened to Detroit infamously on Thanksgiving, when a disputed score by Houston was prevented from review.


Vikings executives hollered at the officials' supervisor in the press box, and mild-mannered coach Leslie Frazier was screaming at referee Mike Carey in search of an explanation.


After posting a 9-23 record over the last two years, the Vikings made so many strides in 2012 that the season was already a success. But no NFL team would ever be satisfied by finishing in defeat against a division rival, and the emotion and energy behind the quest was palpable all afternoon.


The NFC North was sewn up by the Packers two weeks earlier. Even though the bye remained in the balance the top seed didn't do the Packers any good last season. They went 15-1 and lost their opener at home to the eventual champion Giants, the year after winning three straight games on the road to reach and win the Super Bowl.


Rodgers played without injured leading receiver Randall Cobb, so Greg Jennings was the main guy instead, grabbing eight passes for 120 yards and two touchdowns. But the Vikings sacked Rodgers five times, recovering a fumble on one of them. And the defense did just barely enough to keep up with Peterson and end a five-game losing streak to the Packers.


Rodgers has 24 touchdowns, only four interceptions and a 70 percent completion rate over 10 career starts against the Vikings. His poise, arm strength and savvy came through clear against them as much as any other team. Plus, cornerback Antoine Winfield's aggravated hand injury kept him on the sideline for most of the game, a big loss for the Minnesota secondary.


Just as Ponder capably complemented Peterson to give the Vikings a chance, DuJuan Harris came out of nowhere to provide Rodgers some help for the Packers. Green Bay has been proving lately it's not as one-sided an offense as previously believed. Harris rushed 14 times for 70 yards.


With the catch-and-run game they orchestrate so well, finding the soft spots in coverage, the Packers zoomed 80 yards in six plays to pull within 20-17 early in the third quarter. Jennings had a 45-yard gain and the 5-yard grab for a score. He was wide open on both.


But Peterson churned closer to Dickerson on the next drive. Second-and-27? He surged off right tackle and bounced outside for 28 yards. To cap that march, he caught a 2-yard toss from Ponder to push the lead back to 10 points. The "MVP" chants from the crowd rang out in earnest after that.


___


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___


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Dr. Rita Levi-Montalcini, a Revolutionary in the Study of the Brain, Dies at 103


Fabio Campana/European Pressphoto Agency


Rita Levi-Montalcini, the Italian Nobel laureate, in 2007.







Dr. Rita Levi-Montalcini, a Nobel Prize-winning neurologist who discovered critical chemical tools that the body uses to direct cell growth and build nerve networks, opening the way for the study of how those processes can go wrong in diseases like dementia and cancer, died on Sunday at her home in Rome. She was 103.




Her death was announced by Mayor Gianni Alemanno of Rome.


“I don’t use these words easily, but her work revolutionized the study of neural development, from how we think about it to how we intervene,” said Dr. Gerald D. Fishbach, a neuroscientist and professor emeritus at Columbia.


Scientists had virtually no idea how embryo cells built a latticework of intricate connections to other cells when Dr. Levi-Montalcini began studying chicken embryos in the bedroom of her house in Turin, Italy, during World War II. After years of obsessive study, much of it at Washington University in St. Louis with Dr. Viktor Hamburger, she found a protein that, when released by cells, attracted nerve growth from nearby developing cells.


In the early 1950s, she and Dr. Stanley Cohen, a biochemist also at Washington University, isolated and described the chemical, known as nerve growth factor — and in the process altered the study of cell growth and development. Scientists soon realized that the protein gave them a new way to study and understand disorders of neural growth, like cancer, or of degeneration, like Alzheimer’s disease, and to potentially develop therapies.


In the years after the discovery, Dr. Levi-Montalcini, Dr. Cohen and others described a large family of such growth-promoting agents, each of which worked to regulate the growth of specific cells. One, called epidermal growth factor and discovered by Dr. Cohen, plays a central role in breast cancer; in part by studying its behavior, scientists developed drugs to combat the abnormal growth.


In 1986, Dr. Levi-Montalcini and Dr. Cohen shared the Nobel Prize in Physiology or Medicine for their work.


Dr. Cohen, now an emeritus professor at Vanderbilt University, said Dr. Levi-Montalcini possessed a rare combination of intuition and passion, as well as biological knowledge. “She had this feeling for what was happening biologically,” he said. “She was an intuitive observer, and she saw that something was making these nerve connections grow and was determined to find out what it was.”


One of four children, Rita Levi-Montalcini was born in Turin on April 22, 1909, to Adamo Levi, an engineer, and Adele Montalcini, a painter, both Italian Jews who traced their roots to the Roman Empire. In keeping with the Victorian customs of the time, Mr. Levi discouraged his three daughters from entering college, fearing that it would interfere with their lives as wives and mothers.


It was not a future that Rita wanted. She had decided to become a doctor and told her father so. “He listened, looking at me with that serious and penetrating gaze of his that caused me such trepidation,” she wrote in her autobiography, “In Praise of Imperfection” (1988). He also agreed to support her.


She graduated summa cum laude from the University of Turin medical school in 1936. Two years later, Mussolini issued a manifesto barring non-Aryan Italians from having professional careers. She began her research anyway, setting up a small laboratory in her home to study chick embryos, inspired by the work of Dr. Hamburger, a prominent researcher in St. Louis who also worked with the embryos.


During World War II, the family fled Turin for the countryside, and in 1943 the invasion by Germany forced them to Florence. The family returned at the close of the war, in 1945, and Dr. Hamburger soon invited Dr. Levi-Montalcini to work for a year in his lab at Washington University.


She stayed on, becoming an associate professor in 1956 and a full professor in 1958. In 1962, she helped establish the Institute of Cell Biology in Rome and became its first director. She retired from Washington University in 1977, becoming a guest professor and splitting her time between Rome and St. Louis.


Italy honored her in 2001 by making her a senator for life.


An elegant presence, confident and passionate, she was a sought-after speaker until late in life. “At 100, I have a mind that is superior — thanks to experience — than when I was 20,” she said in 2009.


She never married and had no children. In addition to her autobiography, she was the author or co-author of dozens of research studies and received numerous professional awards, including the National Medal of Science.


“It is imperfection — not perfection — that is the end result of the program written into that formidably complex engine that is the human brain,” Dr. Levi-Montalcini wrote in her autobiography, “and of the influences exerted upon us by the environment and whoever takes care of us during the long years of our physical, psychological and intellectual development.”


This article has been revised to reflect the following correction:

Correction: December 30, 2012

An earlier version of this obituary misstated the year Mussolini issued a manifesto barring non-Aryan Italians from having professional careers. It was 1938, not 1936.



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Day Laborers at Premium on Storm-Wrecked Coast


Ozier Muhammad/The New York Times


Reina Vega and Victoriano de la Cruz worked in the cellar of a home in Bay Ridge, Brooklyn.







The day after the storm, Manuel Sinchi, like some other New Yorkers, gathered a few friends, hopped on his bicycle and headed down to badly stricken Coney Island to volunteer his services.




The next day, however, he started offering his services at his usual rate of $15 an hour.


A day laborer for whom making a living in recent years has meant often pointless idling on street corners for increasingly hard-to-get construction work, Mr. Sinchi said that owners of houses ravaged by Hurricane Sandy were now searching him out seven days a week. In the first weeks after the storm, he performed work that required muscle and a strong back, hauling waterlogged sofas and broken refrigerators out of flooded basements, stripping mold-infested walls and sweeping away mounds of sand from front yards. But, as homeowners turned to rebuilding, he has performed more skilled jobs, installing new wallboard, wood floors and bathroom tiles.


There has been so much demand that he was able to buy his two sons in Ecuador a computer, bicycles and new shoes.


“While we have lots of sorrow for those who lost everything, at the same time Sandy has done us a favor by creating jobs that were not there,” Mr. Sinchi said, speaking in Spanish.


His tale of finding fortune along the streets of ruined homes and upended lives is similar to those of hundreds of day laborers in New York City and its coastal suburbs. For a population accustomed to scraping by, Hurricane Sandy has been a boon, conjuring up demolition and construction work that has been mostly absent since the housing market’s collapse and providing a spike in remittances to families in Mexico, Central America and South America.


These mostly Hispanic workers, some of whom are in the country illegally, have suddenly become a ubiquitous and indispensable presence in seaside communities in New York and New Jersey, where residents who might once have spurned hiring them are racing to make their homes livable again as soon as possible. Despite the influx of volunteers — sometimes regarded as competitors by the day laborers — there is so much demand for their services that even women who have typically made a living as domestics are gathering on street corners and in front of hardware stores to help with the grueling work.


“Day laborers are like first responders to this crisis,” said Ligia M. Guallpa, director of the Workers Justice Project, which operates a shack alongside a shopping plaza in Bensonhurst, Brooklyn, where day laborers gather and contractors and homeowners come to hire them. Before the storm, fewer than 15 workers a week were sent out on jobs. Now that number has grown to 45.


In the first week after the storm hit, homeowners were desperate for help getting their lives back to something approaching normal. Some day laborers like Carmelo Hernandez, 46, a Mexican immigrant and tile installer, even bought headlamps so they could work at night, so great was the demand.


More recently, some workers said that jobs had slowed as cleaning up shifted to rebuilding, which had prompted homeowners to turn to licensed professionals for skilled tasks like plumbing, carpentry and electrical work. But other laborers said they expected the volume of work to pick up when homeowners received money from their insurance companies or from the Federal Emergency Management Agency.


Standing on a corner of 69th Street in Woodside, Queens, dozens of men waited in the early morning cold for contractors’ trucks to pass by. Each time a car stopped, the men would sprint to the window. After a brief negotiation — $15 an hour was the going rate, though some agreed to work for less — a few would climb inside and speed off.


One of them, Pedro Cabrera, 28, who is from Mexico, had worked 10 straight days in the Rockaways. Even though one homeowner vanished without paying him, he had made enough to buy new gloves to work in the wet and freezing buildings. Some owners told him to take anything he found, since it was all headed for the trash anyway — even a ring that he was able to pawn for $200 at a jewelry store. Still, it was painful, he said, being watched by a family whose hard-earned belongings he was throwing into the garbage.


Sarah Maslin Nir and Jessica Weisberg contributed reporting.



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India Ink: Delhi Rape Victim's Trauma 'Too Severe to Overcome'

A 23-year-old woman, whose rape in Delhi on Dec. 16 galvanized thousands to protest for better treatment of women, died on Saturday morning. The full statement from Kelvin Loh, chief executive of Mount Elizabeth Hospital, where she was being treated, is below:

“We are very sad to report that the patient passed away peacefully at 4.45am on 29 Dec 2012 (Singapore time). Her family and officials from the High Commission of India were by her side. The Mount Elizabeth Hospital team of doctors, nurses and staff join her family in mourning her loss.”

“The patient had remained in an extremely critical condition since admission to Mount Elizabeth Hospital in the morning of 27 Dec (Singapore time). Despite all efforts by a team of eight specialists in Mount Elizabeth Hospital to keep her stable, her condition continued to deteriorate over these two days. She had suffered from severe organ failure following serious injuries to her body and brain. She was courageous in fighting for her life for so long against the odds but the trauma to her body was too severe for her to overcome.”

“We are humbled by the privilege of being tasked to care for her in her final struggle. We acknowledge the faith the Indian Government and the patient’s family have placed with us to ensure the best care possible was indeed provided to her at Mount Elizabeth Hospital. We share their huge sadness at her passing and will work with the High Commission of India to provide the family support in this time of grief.”

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