49ers use defense to beat Saints, 31-21

NEW ORLEANS (AP) — Ahmad Brooks, Donte Whitner and the rest of the San Francisco defense made enough plays for the 49ers to win no matter who they started at quarterback.

Brooks and Whitner returned interceptions for touchdowns, the 49ers sacked Drew Brees five times, and San Francisco ended the New Orleans Saints' three-game winning streak, 31-21 on Sunday.

Colin Kaepernick was solid in his second career start while Alex Smith, deemed healthy enough to suit up after recovering from a concussion, watched from the sideline. Kaepernick passed for 231 yards, including a short touchdown to Frank Gore. He also ran for a 7-yard score. He threw his first career interception, but it was inconsequential.

Brees finished with 267 yards and three TDs. After rushing for 140 yards or more in each of its previous three games, New Orleans (5-6) managed only 59 yards against San Francisco (8-2-1).

One of Brees' scoring passes went to Marques Colston, who set a Saints record with his 56th career touchdown with the club.

The Niners gained 144 yards on the ground, led by Gore with 83. The Saints shut down tight end Vernon Davis, the player they feared perhaps the most, but the Niners' other tight end, Delanie Walker, had three catches for 81 yards, including one for 45 yards to set up a touchdown.

San Francisco's interceptions turned a 14-7 deficit into a 28-14 lead.

Brooks snagged the first, returning it 50 yards late in the first half. The second came on Brees' first pass of the second half. The ball deflected off Colston's hands as the leaping receiver was upended and briefly shaken up. Whitner snagged the deflected pass and returned it 42 yards to make it 28-14

Since losing to the New York Giants on Oct. 14, the Niners are 5-0-1 and now hold a 2 1/2-game lead in the NFC West with five games to go.

It seems their biggest problem at this point is deciding who should be their No. 1 QB. Smith, who led the Niners to the NFC title game last season, started the first nine games this season before his injury.

The Saints, meanwhile, missed a chance to pull into a tie for the last NFC wild card berth, and remain a game out with another tough game coming up at Atlanta on Thursday night.

Kaepernick used the running ability that served him so well in college at Nevada to give the Niners the early lead, scoring on a read-option run that fooled the Saints defense as well as the Superdome crowd, which erupted, initially believing the play had been snuffed out, while Kaepernick scampered to his left and scored easily.

The drive was highlighted by Mario Manningham's 40-yard gain after Kaepernick found him wide open on a short crossing route.

Then, New Orleans' offense, which could not muster a first down on its first two drives, suddenly ignited, marching 79 yards in 10 plays — highlighted by Joe Morgan's diving 33-yard catch — to tie it on tight end David Thomas' 6-yard catch.

San Francisco entered the game allowing a league-low 13.4 points per game. The Saints surpassed that in the second quarter when Brees hit Colston to make it 14-7 and capitalize on Ted Ginn Jr.'s fumbled punt, which Rafael Bush had recovered on the 49ers 10.

New Orleans looking intent on going up by two scores after Kaepernick's first career interception on an underthrown pass that cornerback Patrick Robinson easily caught. But the crowd has hardly finished celebrating when Brooks stepped in front of Brees' pass for Jimmy Graham and returned it 50 yards to tie it at 14 shortly before halftime.

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M.I.T. Lab Hatches Ideas, and Companies, by the Dozens

HOW do you take particles in a test tube, or components in a tiny chip, and turn them into a $100 million company?

Dr. Robert Langer, 64, knows how. Since the 1980s, his Langer Lab at the Massachusetts Institute of Technology has spun out companies whose products treat cancer, diabetes, heart disease and schizophrenia, among other diseases, and even thicken hair.

The Langer Lab is on the front lines of turning discoveries made in the lab into a range of drugs and drug delivery systems. Without this kind of technology transfer, the thinking goes, scientific discoveries might well sit on the shelf, stifling innovation.

A chemical engineer by training, Dr. Langer has helped start 25 companies and has 811 patents, issued or pending, to his name. That’s not too far behind Thomas Edison, who had 1,093. More than 250 companies have licensed or sublicensed Langer Lab patents.

Polaris Venture Partners, a Boston venture capital firm, has invested $220 million in 18 Langer Lab-inspired businesses. Combined, these businesses have improved the health of many millions of people, says Terry McGuire, co-founder of Polaris.

Along the way, Dr. Langer and his lab, including about 60 postdoctoral and graduate students at a time, have found a way to navigate some slippery territory: the intersection of academic research and the commercial market.

Over the last 30 years, many universities — including M.I.T. — have set up licensing offices that oversee the transfer of scientific discoveries to companies. These offices have become a major pathway for universities seeking to put their research to practical use, not to mention add to their revenue streams.

In the sciences in particular, technology transfer has become a key way to bring drugs and other treatments to market. “The model of biomedical innovation relies on research coming out of universities, often funded by public money,” says Josephine Johnston, director of research at the Hastings Center, a bioethics research organization based in Garrison, N.Y.

Just a few of the products that have emerged from the Langer Lab are a small wafer that delivers a dose of chemotherapy used to treat brain cancer; sugar-sequencing tools that can be used to create new drugs like safer and more effective blood thinners; and a miniaturized chip (a form of nanotechnology) that can test for diseases.

The chemotherapy wafer, called the Gliadel, is licensed by Eisai Inc. The company behind the sugar-sequencing tools, Momenta Pharmaceuticals, raised $28.4 million in an initial public offering in 2004. The miniaturized chip is made by T2Biosystems,  which completed a $23 million round of financing in the summer of 2011.

“It’s inconvenient to have to send things to a lab,” so the company is trying to develop more sophisticated methods, says Dr. Ralph Weissleder, a co-founder, with Dr. Langer and others, of T2Biosystems and a professor at Harvard Medical School.

FOR Dr. Langer, starting a company is not the same as it was, say, for Mark Zuckerberg with Facebook. “Bob is not consumed with any one company,” says H. Kent Bowen, an emeritus professor of business administration at Harvard Business School who wrote a case study on the Langer Lab. “His mission is to create the idea.”

Dr. Bowen observes that there are many other academic laboratories, including highly productive ones, but that the Langer Lab’s combination of people, spun-out companies and publications sets it apart. He says Dr. Langer “walks into the great unknown and then makes these discoveries.”

Dr. Langer is well known for his mentoring abilities. He is “notorious for replying to e-mail in two minutes, whether it’s a lowly graduate school student or the president of the United States,” says Paulina Hill, who worked in his lab from 2009 to 2011 and is now a senior associate at Polaris Venture Partners. (According to Dr. Langer, he has corresponded directly with President Obama about stem cell research and federal funds for the sciences.)

Dr. Langer says he looks at his students “as an extended family,” adding that “I really want them to do well.”

And they have, whether in business or in academia, or a combination of the two. One former student, Ram Sasisekharan, helped found Momenta and now runs his own lab at M.I.T. Ganesh Venkataraman Kaundinya is Momenta’s chief scientific officer and senior vice president for research.

Hongming Chen is vice president of research at Kala Pharmaceuticals. Howard Bernstein is chief scientific officer at Seventh Sense Biosystems, a blood-testing company. Still others have taken jobs in the law or in government.

Dr. Langer says he spends about eight hours a week working on companies that come out of his lab. Of the 25 that he helped start, he serves on the boards of 12 and is an informal adviser to 4. All of his entrepreneurial activity, which includes some equity stakes, has made him a millionaire. But he says he is mainly motivated by a desire to improve people’s health.

Operating from the sixth floor of the David H. Koch Institute for Integrative Cancer Research on the M.I.T. campus in Cambridge, Mass., Dr. Langer’s lab has a research budget of more than $10 million for 2012, coming mostly from federal sources.

The research in labs like Dr. Langer’s is eyed closely by pharmaceutical companies. While drug companies employ huge research and development teams, they may not be as freewheeling and nimble, Dr. Langer says. The basis for many long-range discoveries has “come out of academia, including gene therapy, gene sequencing and tissue engineering,” he says.

He has served as a consultant to pharmaceutical companies. Their large size, he says, can end up being an impediment.

“Very often when you are going for real innovation,” he says, “you have to go against prevailing wisdom, and it’s hard to go against prevailing wisdom when there are people who have been there for a long time and you have some vice president who says, ‘No, that doesn’t make sense.’ ”

Pharmaceutical companies are eager to tap into the talent at leading research universities. In 2008, for example, Washington University in St. Louis announced a $25 million pact with Pfizer to collaborate more closely on biomedical research.

But in some situations, the close — critics might say cozy — ties between business and academia have the potential to create conflicts of interest.

There was a controversy earlier this year when it was revealed that the president of the University of Texas M.D. Anderson Cancer Center owned stock in Aveo Oncology, which had announced earlier that the university would be leading clinical trials of one of its cancer drugs.  Last month, the University of Texas announced that he would be allowed to keep his ties with three pharmaceutical companies, including Aveo Oncology; his holdings will be placed in a blind trust.

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Legality of Warrantless Cellphone Searches Goes to Courts and Legislatures

Judges and lawmakers across the country are wrangling over whether and when law enforcement authorities can peer into suspects’ cellphones, and the cornucopia of evidence they provide.

Peter DaSilva for The New York Times

Organizations like the Electronic Frontier Foundation, where Hanni Fakhoury is a lawyer, have lobbied for legislation that would require authorities to obtain a warrant before demanding cellphone location records.

A Rhode Island judge threw out cellphone evidence that led to a man being charged with the murder of a 6-year-old boy, saying the police needed a search warrant. A court in Washington compared text messages to voice mail messages that can be overheard by anyone in a room and are therefore not protected by state privacy laws.

In Louisiana, a federal appeals court is weighing whether location records stored in smartphones deserve privacy protection, or whether they are “business records” that belong to the phone companies.

“The courts are all over the place,” said Hanni Fakhoury, a criminal lawyer with the Electronic Frontier Foundation, a San Francisco-based civil liberties group. “They can’t even agree if there’s a reasonable expectation of privacy in text messages that would trigger Fourth Amendment protection.”

The issue will attract attention on Thursday when a Senate committee considers limited changes to the Electronic Communications Privacy Act, a 1986 law that regulates how the government can monitor digital communications. Courts have used it to permit warrantless surveillance of certain kinds of cellphone data.

A proposed amendment would require the police to obtain a warrant to search e-mail, no matter how old it was, updating a provision that currently allows warrantless searches of e-mails more than 180 days old.

As technology races ahead of the law, courts and lawmakers are still trying to figure out how to think about the often intimate data that cellphones contain, said Peter P. Swire, a law professor at Ohio State University. Neither the 1986 statute nor the Constitution, he said, could have anticipated how much information cellphones are privy to, including detailed records of people’s travels and diagrams of their friends.

“It didn’t take into account what the modern cellphone has — your location, the content of communications that are easily readable, including Facebook posts, chats, texts and all that stuff,” Mr. Swire said.

Courts have also issued divergent rulings on when and how cellphones can be inspected. An Ohio court ruled that the police needed a warrant to search a cellphone because, unlike a piece of paper that might be stuffed inside a suspect’s pocket and can be confiscated during an arrest, a cellphone may hold “large amounts of private data.”

But California’s highest court said the police could look through a cellphone without a warrant so long as the phone was with the suspect at the time of arrest.

Judges across the nation have written tomes about whether a cellphone is akin to a “container” — like a suitcase stuffed with marijuana that the police might find in the trunk of a car — or whether, as the judge in the Rhode Island murder case suggested, it is more comparable to a face-to-face conversation. That judge, Judith C. Savage, described text messages as “raw, unvarnished and immediate, revealing the most intimate of thoughts and emotions.” That is why, she said, citizens can reasonably expect them to be private.

There is little disagreement about the value of cellphone data to the police. In response to a Congressional inquiry, cellphone carriers said they responded in 2011 to 1.3 million demands from law enforcement agencies for text messages and other information about subscribers.

Among the most precious information in criminal inquiries is the location of suspects, and when it comes to location records captured by smartphones, court rulings have also been inconsistent. Privacy advocates say a trail of where people go is inherently private, while law enforcement authorities say that consumers have no privacy claim over signals transmitted from an individual mobile device to a phone company’s communications tower, which they refer to as third-party data.

Delaware, Maryland and Oklahoma have proposed legislation that would require the police to obtain a warrant before demanding location records from cellphone carriers. California passed such a law in August after intense lobbying by privacy advocates, including Mr. Fakhoury’s group. But Gov. Jerry Brown, a Democrat, vetoed the bill, questioning whether it struck “the right balance between the operational needs of law enforcement and individual expectations of privacy.”

Similar legislation has been proposed in Congress.

Lacking a clear federal statute, the courts have been unable to reach a consensus. In Texas, a federal appeals court said this year that law enforcement officials did not need a warrant to track suspects through cellphones. In Louisiana, another federal appeals court is considering a similar case. Prosecutors are arguing that location information is part of cellphone carriers’ business records and thus not constitutionally protected.

The Supreme Court has not directly tackled the issue, except to declare, in a landmark ruling this year, that the police must obtain a search warrant to install a GPS tracking device on someone’s private property.

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Morsi Urged to Retract Edict to Bypass Judges in Egypt

Tara Todras-Whitehill for The New York Times

Protesters lit flares and denounced the edict of President Mohamed Morsi during clashes with riot police officers in front of the high court building in Cairo on Saturday. More Photos »

CAIRO — Egyptian judges rebelled Saturday against an edict by President Mohamed Morsi exempting his decrees from judicial review, denouncing it as an attack on judicial independence and calling for a judges’ strike.

The condemnation came from an array of organizations. The Supreme Council of the Judiciary, a top judicial body, called the decree “an unprecedented attack on judicial independence” and urged the president to rescind it. A major association of judges, the Judges Club, called for a strike by courts across Egypt. The leader of the national lawyers’ association endorsed the strike call.

A judicial strike would be the steepest escalation yet in a political struggle between the country’s new Islamist leaders and the institutions of the old authoritarian government over the drafting of a new constitution. Those tensions have flared since Mr. Morsi announced his decree on Thursday, saying he acted to prevent the courts from dissolving the Constitutional Assembly, as they had dissolved an earlier assembly and the Parliament.

He said his expanded powers, which he announced a day after he won international praise for brokering a cease-fire in Gaza, would last only until the new constitution was ratified.

The judges, all of whom were appointed by Egypt’s ousted strongman, Hosni Mubarak, joined political leaders in opposing the decree. Because the court dissolved the Parliament, the judiciary was the last check on his power, and critics called the decree a step toward autocracy.

State news media reported that judges and prosecutors had already declared a strike in Alexandria, and there were other news reports of planned walkouts in Qulubiya and Beheira, but those could not be confirmed.

There were small street protests outside the court building where the judges met. And a coalition of disparate opposition leaders, including the former United Nations diplomat Mohamed ElBaradei and three other former Egyptian presidential candidates, demanded the cancellation of the decree.

The strike call by the Judges Club, which has been led in recent years by a clique loyal to Mr. Mubarak and opposed to the Islamists, followed a vote at a more representative assembly of about 1,000 of the club’s members. They urged courts to suspend all activities except those vital to citizens, and it was unclear how individual courts might respond.

As the Judges Club met in the High Court building, the small crowd of protesters outside chanted that Egypt’s judges were “a red line.” When another group armed with the flares favored by hard-core soccer fans tried to force their way into the building, the police fired tear gas.

Inside, the Mubarak-appointed chief prosecutor, Abdel Meguid Mahmoud, declared to a crowd of cheering judges that he rejected Mr. Morsi’s attempt to fire him. He called the presidential decree “null and void” and warned of a “systematic campaign against the country’s institutions in general and the judiciary in particular.” Judges in the meeting chanted for the “fall of the regime,” reprising the signature rallying cry of the revolt last year against Mr. Mubarak, but this time against Mr. Morsi.

Khaled Ali, a human rights lawyer, said he had filed one of several lawsuits asking the courts to attempt to overturn Mr. Morsi’s decree.

The coalition of opposition leaders, calling their group the National Salvation Front, declared that it would not negotiate with Mr. Morsi about resolving the crisis until he withdrew his decree. “We will not enter into a dialogue about anything while this constitutional declaration remains intact and in force,” said Amr Moussa, one of the leaders and Mr. Mubarak’s former foreign minister. “We demand that it be withdrawn, and then we can talk.”

What set off the battle was the year-end deadline for the Constitutional Assembly chosen last spring to draft a new constitution. There have been rumors that the Supreme Constitutional Court was poised to dissolve the assembly in a ruling next Sunday. Top courts had already dissolved both an earlier Constitutional Assembly and the Parliament. All three bodies were dominated by Islamists, who have prevailed in elections, and many of the top judges harbor deep fears of an Islamist takeover.

Kareem Fahim, Nevine Ramzy and Mai Ayyad contributed reporting.

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No. 6 Florida rolls to 37-26 win over No. 10 FSU

TALLAHASSEE, Fla. (AP) — Florida coach Will Muschamp doesn't have any doubt where his team's next stop should be: Miami for the BCS championship game on Jan. 7.

And the sixth-ranked Gators made a strong case for consideration Saturday by crushing archrival Florida State.

Mike Gillislee ran for two touchdowns and Florida scored 24 straight points in a span of less than nine minutes in the fourth quarter to keep its national title hopes alive with a convincing win over the 10th-ranked Seminoles.

"We have a really tough football team," Muschamp said he left the field for Florida's locker room. "We should be playing for the national championship."

Florida (11-1, 7-1 Southeastern Conference) came into the game fourth in the BCS standings, and could find itself in position to earn a spot in the national championship game if No. 1 Notre Dame loses to Southern California. The Gators lone loss was in late October to third-ranked Georgia, and it will keep them out of the SEC title game.

"Hopefully we can sneak in," said Florida quarterback Jeff Driskel, who completed 15 of 23 passes for 147 yards and a touchdown. "We're a resilient team."

He's not likely to get any argument from Florida State coach Jimbo Fisher, who hoped a victory over the Gators would not only persuade pollsters that the Seminoles belonged among the elite, but win some positive attention for the Atlantic Coast Conference.

"They controlled the line of scrimmage up front," Fisher said. "They have a very good team. They did a great job."

The game matching two of the nation's best defenses went back and forth with the Seminoles scoring 20 unanswered points to take a 20-13 lead late in the third quarter. They wouldn't score again until the final play of the game and victory out of reach.

"Our guys understand that it's about all 60 minutes," Muschamp said. "We just really needed to be patient and wear them down."

Did they ever.

Florida regained the lead for keeps at 23-20 on Gillislee's 37-yard run with 11:01 left in the final period on the first play after Florida State's EJ Manuel fumbled, his fourth turnover of the game. Gillislee finished with 140 yards rushing, surpassing the 1,000-yard mark for the season early in the game.

Florida State (10-2, 7-1 Atlantic Coast Conference) was hurt by five turnovers in the game. The Seminoles will play Georgia Tech next week in the ACC title game.

Florida State was hoping to keep its own long shot national title hopes alive with a third straight win over the Gators, but couldn't.

The Seminoles had been so dominant at home, outscoring opponents 324-54 in six previous games here with Clemson doing the most damage when Florida State prevailed in a 49-37 shootout in September.

Florida, not known for its offense, rushed for 244 of its 394 yards against the nation's top-ranked defense, which has benefited from a comparatively weak schedule.

And it was that schedule and a 17-16 loss at North Carolina State last month that has provoked questions about how good the Seminoles were. They couldn't capitalize on the opportunity to prove the doubters wrong.

"We're better than them," Florida nose guard Omar Hunter said. "You have to finish the game. The fourth quarter, that's the most important quarter."

Florida salted its victory away on Driskel's 14-yard touchdown throw to Quinton Dunbar with seven minutes left and Matt Jones' 32-yard run with 2:33 left for a 37-20 lead.

Caleb Sturgis kicked three field goals for the Gators. Florida State's Dustin Hopkins had field goals of 50 and 53 yards to tie former Georgia kicker Billy Bennett's NCAA record of 87 career field goals.

Florida State scored 20 straight points to wipe out an early 13-0 deficit. Manuel threw a 6-yard TD pass to Nick O'Leary and the quarterback bootlegged in from a yard out with 8:30 remaining. When Dustin Hopkins kicked a 53-yard field goal with 4:24 left in the third, the Seminoles looked as if they were on their way.

But Florida dominated the fourth quarter.

Gillislee's go-ahead TD run came the first play after Florida's Dominque Easley recovered the fumble by Manuel, who coughed up the ball after being nailed by Antonio Morrison. Manuel had to leave the game for a series, but was unable to rally the Seminoles after returning.

It was a tough game for Manuel for the second straight year against the Gators. He threw for only 65 yards in a 21-7 win at Florida last season and was intercepted three times Saturday in addition to the costly fourth quarter fumble. It was only the second time he was intercepted three times in a game in his career.

Florida dominated the first half, building a 13-0 lead before Florida State scored on the final play of the half when Hopkins kicked a 50-yard field goal into the wind.

Sturgis hit field goals of 39 and 45 yards and Gillislee scored on a 9-yard run moments after the Gators recovered a fumble on the kickoff by Florida State's Karlos Williams at the Seminoles 21.

The Gators, who missed a golden scoring opportunity near the end of the first quarter when Trey Burton underthrew a wide open Clay Burton at about the Florida State 10, ran 25 plays in the opening quarter to eight for the Seminoles.

By the time the fourth quarter rolled around, Florida State seemed to wear down and Florida rolled right into the middle of the national championship conversation.

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Indian Prostitutes’ New Autonomy Imperils AIDS Fight

Kuni Takahashi for The New York Times

Sex workers in Mumbai’s long-established red-light district, where brothels are dwindling.

MUMBAI, India — Millions once bought sex in the narrow alleys of Kamathipura, a vast red-light district here. But prostitutes with inexpensive mobile phones are luring customers elsewhere, and that is endangering the astonishing progress India has made against AIDS.

Indeed, the recent closings of hundreds of ancient brothels, while something of an economic victory for prostitutes, may one day cost them, and many others, their lives.

“The place where sex happens turns out to be an important H.I.V. prevention point,” said Saggurti Niranjan, program associate of the Population Council. “And when we don’t know where that is, we can’t help stop the transmission.”

Cellphones, those tiny gateways to modernity, have recently allowed prostitutes to shed the shackles of brothel madams and strike out on their own. But that independence has made prostitutes far harder for government and safe-sex counselors to trace. And without the advice and free condoms those counselors provide, prostitutes and their customers are returning to dangerous ways.

Studies show that prostitutes who rely on cellphones are more susceptible to H.I.V. because they are far less likely than their brothel-based peers to require their clients to wear condoms.

In interviews, prostitutes said they had surrendered some control in the bedroom in exchange for far more control over their incomes.

“Now, I get the full cash in my hand before we start,” said Neelan, a prostitute with four children whose side business in sex work is unknown to her husband and neighbors. (Neelan is a professional name, not her real one.)

“Earlier, if the customer got scared and didn’t go all the way, the madam might not charge the full amount,” she explained. “But if they back out now, I say that I have removed all my clothes and am going to keep the money.”

India has been the world’s most surprising AIDS success story. Though infections did not appear in India until 1986, many predicted the nation would soon become the epidemic’s focal point. In 2002, the C.I.A.’s National Intelligence Council predicted that India would have as many as 25 million AIDS cases by 2010. Instead, India now has about 1.5 million.

An important reason the disease never took extensive hold in India is that most women here have fewer sexual partners than in many other developing countries. Just as important was an intensive effort underwritten by the World Bank and the Bill and Melinda Gates Foundation to target high-risk groups like prostitutes, gay men and intravenous drug users.

But the Gates Foundation is now largely ending its oversight and support for AIDS prevention in India, just as efforts directed at prostitutes are becoming much more difficult. Experts say it is too early to identify how much H.I.V. infections might rise.

“Nowadays, the mobility of sex workers is huge, and contacting them is very difficult,” said Ashok Alexander, the former director in India of the Gates Foundation. “It’s a totally different challenge, and the strategies will also have to change.”

An example of the strategies that had been working can be found in Delhi’s red-light district on Garstin Bastion Road near the old Delhi railway station, where brothels have thrived since the 16th century. A walk through dark alleys, past blind beggars and up narrow, steep and deeply worn stone staircases brings customers into brightly lighted rooms teeming with scores of women brushing each other’s hair, trying on new dresses, eating snacks, performing the latest Bollywood dances, tending small children and disappearing into tiny bedrooms with nervous men who come out moments later buttoning their trousers.

A 2009 government survey found 2,000 prostitutes at Garstin Bastion (also known as G. B.) Road who served about 8,000 men a day. The government estimated that if it could deliver as many as 320,000 free condoms each month and train dozens of prostitutes to counsel safe-sex practices to their peers, AIDS infections could be significantly reduced. Instead of broadcasting safe-sex messages across the country — an expensive and inefficient strategy commonly employed in much of the world — it encircled Garstin Bastion with a firebreak of posters with messages like “Don’t take a risk, use a condom” and “When a condom is in, risk is out.”

Surprising many international AIDS experts, these and related tactics worked. Studies showed that condom use among clients of prostitutes soared.

“To the credit of the Indian strategists, their focus on these high-risk groups paid off,” said Dr. Peter Piot, the former executive director of U.N.AIDS and now director of the London School of Hygiene and Tropical Medicine. A number of other countries, following India’s example, have achieved impressive results over the past decade as well, according to the latest United Nations report, which was released last week.

Sruthi Gottipati contributed reporting in Mumbai and New Delhi.

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Insurer’s Regulatory Win Benefits a Chinese Leader’s Family

Gilles Sabrie for The New York Times

Ping An, one of China’s largest financial services companies, is building a 115-story office tower in Shenzhen. The company is a $50 billion powerhouse now worth more than A.I.G., MetLife or Prudential.

SHENZHEN, China — The head of a financially troubled insurer was pushing Chinese officials to relax rules that required breaking up the company in the aftermath of the Asian financial crisis.

The survival of Ping An Insurance was at stake, officials were told in the fall of 1999. Direct appeals were made to the vice premier at the time, Wen Jiabao, as well as the then-head of China’s central bank — two powerful officials with oversight of the industry.

“I humbly request that the vice premier lead and coordinate the matter from a higher level,” Ma Mingzhe, chairman of Ping An, implored in a letter to Mr. Wen that was reviewed by The New York Times.

Ping An was not broken up.

The successful outcome of the lobbying effort would prove monumental.

Ping An went on to become one of China’s largest financial services companies, a $50 billion powerhouse now worth more than A.I.G., MetLife or Prudential. And behind the scenes, shares in Ping An that would be worth billions of dollars once the company rebounded were acquired by relatives of Mr. Wen.

The Times reported last month that the relatives of Mr. Wen, who became prime minister in 2003, had grown extraordinarily wealthy during his leadership, acquiring stakes in tourist resorts, banks, jewelers, telecommunications companies and other business ventures.

The greatest source of wealth, by far, The Times investigation has found, came from the shares in Ping An bought about eight months after the insurer was granted a waiver to the requirement that big financial companies be broken up.

Long before most investors could buy Ping An stock, Taihong, a company that would soon be controlled by Mr. Wen’s relatives, acquired a large stake in Ping An from state-owned entities that held shares in the insurer, regulatory and corporate records show. And by all appearances, Taihong got a sweet deal. The shares were bought in December 2002 for one-quarter of the price that another big investor — the British bank HSBC Holdings — paid for its shares just two months earlier, according to interviews and public filings.

By June 2004, the shares held by the Wen relatives had already quadrupled in value, even before the company was listed on the Hong Kong Stock Exchange. And by 2007, the initial $65 million investment made by Taihong would be worth $3.7 billion.

Corporate records show that the relatives’ stake of that investment most likely peaked at $2.2 billion in late 2007, the last year in which Taihong’s shareholder records were publicly available. Because the company is no longer listed in Ping An’s public filings, it is unclear if the relatives continue to hold shares.

It is also not known whether Mr. Wen or the central bank chief at the time, Dai Xianglong, personally intervened on behalf of Ping An’s request for a waiver, or if Mr. Wen was even aware of the stakes held by his relatives.

But internal Ping An documents, government filings and interviews with bankers and former senior executives at Ping An indicate that both the vice premier’s office and the central bank were among the regulators involved in the Ping An waiver meetings and who had the authority to sign off on the waiver.

Only two large state-run financial institutions were granted similar waivers, filings show, while three of China’s big state-run insurance companies were forced to break up. Many of the country’s big banks complied with the breakup requirement — enforced after the financial crisis because of concerns about the stability of the financial system — by selling their assets in other institutions.

Ping An issued a statement to The Times saying the company strictly complies with rules and regulations, but does not know the backgrounds of all entities behind shareholders. The company also said “it is the legitimate right of shareholders to buy and sell shares between themselves.”

In Beijing, China’s foreign ministry did not return calls seeking comment for this article. Earlier, a Foreign Ministry spokesman sharply criticized the investigation by The Times into the finances of Mr. Wen’s relatives, saying it “smears China and has ulterior motives.”

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Protests Erupt After Egypt’s Leader Seizes New Power

CAIRO — Protests erupted across Egypt on Friday, as opponents of President Mohamed Morsi clashed with his supporters over a presidential edict that gave him unchecked authority and polarized an already divided nation while raising a specter, the president’s critics charged, of a return to autocracy.  

Maya Alleruzzo/Associated Press

Egyptian protesters chanted antigovernment slogans and waved a national flag in Tahrir Square on Friday.

In an echo of the uprising 22 months ago, thousands of protesters chanted for the downfall of Mr. Morsi’s government in Cairo, while others ransacked the offices of the president’s former party in Suez, Alexandria and other cities.

Mr. Morsi spoke to his supporters in front of the presidential palace here, imploring the public to trust his intentions as he cast himself as a protector of the revolution and a fledgling democracy.

In a speech that was by turns defensive and conciliatory, he ultimately gave no ground to the critics who now were describing him as a pharaoh, in another echo of the insult once reserved for the deposed president, Hosni Mubarak.

“God’s will and elections made me the captain of this ship,” Mr. Morsi said.

The battles that raged on Friday — over power, legitimacy and the mantle of the revolution — posed a sharp challenge not only to Mr. Morsi but also to his opponents, members of secular, leftist and liberal groups whose crippling divisions have stifled their agenda and left them unable to confront the more popular Islamist movement led by the Muslim Brotherhood.

The crisis over his power grab came just days after the Islamist leader won international praise for his pragmatism, including from the United States, for brokering a cease-fire between Hamas and Israel.

On Friday, the State Department expressed muted concern over Mr. Morsi’s decision. “One of the aspirations of the revolution was to ensure that power would not be overly concentrated in the hands of any one person or institution,” said the State Department spokeswoman, Victoria Nuland.

She said, “The current constitutional vacuum in Egypt can only be resolved by the adoption of a constitution that includes checks and balances, and respects fundamental freedoms, individual rights and the rule of law consistent with Egypt’s international commitments.”

But the White House was notably silent after it had earlier this week extolled the emerging relationship between President Obama and Mr. Morsi and credited a series of telephone calls between the two men with helping to mediate the cease-fire in Gaza.

For Mr. Morsi, who seemed to be saying to the nation that it needed to surrender the last checks on his power in order to save democracy from Mubarak-era judges, the challenge was to convince Egyptians that the ends justified his means.

But even as he tried, thousands of protesters marched to condemn his decision. Clashes broke out between the president’s supporters and his critics, and near Tahrir Square, the riot police fired tear gas and bird shot as protesters hurled stones and set fires.

Since Thursday, when Mr. Morsi issued the decree, the president and his supporters have argued that he acted precisely to gain the power to address the complaints of his critics, including the families of protesters killed during the uprising and its aftermath.

By placing his decisions above judicial review, the decree enabled him to replace a public prosecutor who had failed to win convictions against senior officers implicated in the killings of protesters.

The president and his supporters also argued that the decree insulated the Constituent Assembly, which is drafting the constitution, from meddling by Mubarak-era judges.

Since Mr. Mubarak’s ouster, courts have dissolved Parliament, kept a Mubarak loyalist as top prosecutor and disbanded the first Assembly.

But by ending legal appeals, the decree also removed a safety valve for critics who say the Islamist majority is dominating the drafting of the constitution.

Mayy El Sheikh contributed reporting from Cairo, and Helene Cooper from Washington.

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NFL to examine replay rule from Lions-Texans game

NEW YORK (AP) — The rule that negated using video replay to confirm a Houston Texans touchdown "may be too harsh" and will be re-examined immediately, NFL director of football operations Ray Anderson said Friday.

Anderson, also co-chairman of the competition committee that suggests rules changes to the owners, said a change could come this year. The NFL traditionally resists changing rules during a season.

"We will certainly discuss the rule with the competition committee members, as we do all situations involving unique and unusual circumstances, and determine if we feel a change should be recommended to ownership," Anderson said in a statement.

"Not being able to review a play in this situation may be too harsh, and an unintended consequence of trying to prevent coaches from throwing their challenge flag for strategic purposes in situations that are not subject to a coaches' challenge."

Anderson added the NFL is not bound by past events when a rule is proved to have loopholes, and that a 15-yard penalty for throwing the challenge flag on a play that is automatically reviewed might be enough. For now, throwing the challenge flag also eliminates the use of replay. All scoring plays otherwise are reviewed.

Justin Forsett's third-quarter 81-yard run in the Texans' 34-31 overtime victory at Detroit on Thursday initially was ruled a touchdown, although replays clearly showed his knee and elbow touched the turf when he was hit by Lions defenders. Detroit coach Jim Schwartz challenged, resulting in a 15-yard unsportsmanlike conduct penalty and the negated use of video replay.

"I overreacted," Schwartz acknowledged. "And I cost us."

In 2011, instant replay rules were changed to have the replay official initiate a review of all scoring plays. The rule stated that a team is prevented from challenging a play if that team commits a foul that prevents the next snap, or if a challenge flag is thrown when an automatic review would take place. A 15-yard unsportsmanlike conduct penalty is assessed as well as the elimination of the replay review for the play.

But, as Anderson noted, getting the calls right is paramount and that the league may have overlooked the scenario that occurred in Detroit.

Anderson also said the play in which Lions defensive tackle Ndamukong Suh kicked Texans quarterback Matt Schaub in the groin will be reviewed. He called the play "out of the ordinary."

Suh could face a suspension if he is found to have intentionally kicked Schaub. A year ago on Thanksgiving, Suh was ejected for stomping on the right arm of Green Bay offensive lineman Evan Dietrich-Smith and subsequently was suspended for two games.

Suh has been fined in previous seasons for roughing up quarterbacks Andy Dalton, Jay Cutler and Jake Delhomme.

Similar incidents to the replay flap, but not involving scores happened last season in San Francisco's win, coincidentally at Detroit, and last week when the Falcons beat Arizona.

The rule was adopted in part because of a situation in a Redskins-Giants game in December 2010.

Officials on the field ruled a fumble recovered by the Giants, and the ball was made ready for play. But Washington veteran linebacker London Fletcher kicked the ball and was called for delay of game. While the penalty was being enforced, Washington challenged the ruling of a fumble.

The competition committee felt that a team could benefit from committing a penalty in that situation, giving it more time to challenge a play. It was decided that the new rule would also apply when a team throws the challenge flag on a play that can't be challenged — including scoring plays, turnovers, when the team is out of challenges or timeouts, and inside the final two minutes of a half or game, or in overtime.

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Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

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Inquiry Sought in Death in Ireland After Abortion Was Denied

DUBLIN — India’s ambassador here has agreed to ask Prime Minister Enda Kenny of Ireland for an independent inquiry into the death of an Indian-born woman last month after doctors refused to perform an abortion when she was having a miscarriage, the lawyer representing the woman’s husband said Thursday.

The lawyer, Gerard O’Donnell, also said crucial information was missing from the files he had received from the Irish Health Service Executive about the death of the woman, Savita Halappanavar, including any mention of her requests for an abortion after she learned that the fetus would not survive.

The death of Dr. Halappanavar, 31, a dentist who lived near Galway, has focused global attention on the Irish ban on abortion.

Her husband, Praveen Halappanavar, has refused to cooperate with an investigation being conducted by the Irish health agency. “I have seen the way my wife was treated in the hospital, so I have no confidence that the H.S.E. will do justice,” he said in an interview on Wednesday night on RTE, the state television broadcaster. “Basically, I don’t have any confidence in the H.S.E.”

In a tense debate in the Irish Parliament on Wednesday evening, Robert Dowds of the Labour Party said Dr. Halappanavar’s death had forced politicians “to confront an issue we have dodged for much too long,” partly because so many Irish women travel to Britain for abortions.

“The reality is that if Britain wasn’t on our doorstep, we would have had to introduce abortion legislation years ago to avoid women dying in back-street abortions,” he said.

After the debate, the Parliament voted 88 to 53 against a motion introduced by the opposition Sinn Fein party calling on the government to allow abortions when women’s lives are in danger and to protect doctors who perform such procedures.

The Irish president, Michael D. Higgins — who is restricted by the Constitution from getting involved in political matters — also made a rare foray into a political debate on Wednesday, saying any inquiry must meet the needs of the Halappanavar family as well as the government.

In 1992, the Irish Supreme Court interpreted the current law to mean that abortion should be allowed in circumstances where there was “a real and substantial risk to the life of the mother,” including the threat of suicide. But that ruling has never been codified into law.

“The current situation is like a sword of Damocles hanging over us,” Dr. Peter Boylan, of the Irish Institute of Obstetricians and Gynecologists, told RTE last week. “If we do something with a good intention, but it turns out to be illegal, the consequences are extremely serious for medical practitioners.”

Dr. Ruth Cullen, who has campaigned against abortion, said that any legislation to codify the Supreme Court ruling would be tantamount to allowing abortion on demand and that Dr. Halappanavar’s death should not be used to make that change.

Dr. Halappanavar contracted a bacterial blood infection, septicemia, and died Oct. 28, a week after she was admitted to Galway University Hospital with severe back pains. She was 17 weeks pregnant but having a miscarriage and was told that the fetus — a girl — would not survive. Her husband said she asked several times for an abortion but was informed that under Irish law it would be illegal while there was a fetal heartbeat, because “this is a Catholic country.”

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